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Different Mutational Pathways to CXCR4 Coreceptor Switch

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UvA-DARE (Digital Academic Repository) Within-host HIV-1 evolution in relation to viral coreceptor use and host environment Edo Matas,

Different selective pressures could play a role in the emergence of CXCR4-using variants such as host neutralizing antibodies (nAbs) ... are suf!cient for a switch from CCR5 to CXCR4 coreceptor use48,58,61-65, emergence of CXCR4-using variants would be ...

Understanding the HIV coreceptor switch from a dynamical perspective | SpringerLi

This preference changes however in about 50% of patients during the course of disease towards viruses using the CXCR4 coreceptor (X4 viruses). This switch in coreceptor usage is associated with a ...

R5X4 Viruses Are Evolutionary, Functional, and Antigenic .

To examine the pathway of the coreceptor switching of CCR5-using (R5) virus to CXCR4-using (X4) virus in simian-human immunodeficiency virus SHIV SF162P3N-infected rhesus macaque BR24, analysis was performed on variants present at 20 weeks postinfection, the time when the signature gp120 V3 loop sequence of the X4 switch variant was first detected by PCR.

Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIV SF162P3N molecular clones in rhesus macaques | Retrovirology .

Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIV SF162P3N molecular clones in rhesus macaques Wuze Ren 1, Alexandra Mumbauer 1, ...

CiteSeerX — Adoption of an ‘‘Open’ ’ Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch .

greater structural flexibility to accommodate further mutational changes that confer CXCR4 utilization. We show that, ... Adoption of an ‘‘Open’ ’ Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch ...

Structural basis of coreceptor recognition by HIV-1 .

The cryo-electron microscopy structure of the gp120 component of the HIV-1 envelope glycoprotein, in complex with the primary receptor CD4 and coreceptor CCR5, provides insight into the cell-entry ...

Transitions from CCR5 to CXCR4 use in the absence of antiretroviral drug pressure proceed incrementally and may occur through a multitude of .

Virus populations at the time of the coreceptor switch were comprised of mixtures of R5- and dual ... of emerging CXCR4-using variants in the virus populations of eight individuals indicates that HIV uses a multitude of mutational pathways to transition from CCR5 ...

HIV coreceptor tropism determination and mutational .

As infection progresses, the virus evolves and may exhibit a coreceptor-switch to CXCR4. Accurate determination coreceptor usage and identification key mutational patterns associated tropism ...

CD4-Dependent Characteristics of Coreceptor Use and HIV Type 1 V3 Sequence in a Large Population of Therapy-Naive Individuals | AIDS Research and .

Adoption of an “Open” Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch in R5 SHIV-Infected Macaques ...

WIReDSpace: In vitro and in vivo diversity of HIV-1 subtype C envelope proteins and correlation with changes in biological properties of viral .

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Human immunodeficiency virus type 1 biological variation and coreceptor use: from concept to clinical significance - Fenyö - 2011 - Journal of .

Evolution often involves switch of coreceptor use from CCR5 to CXCR4, but change to more flexible use of CCR5 occurs over time even in patients with maintained CCR5 use. ...

CD4-Dependent Characteristics of Coreceptor Use and HIV Type 1 V3 Sequence in a Large Population of Therapy-Naive Individuals | AIDS Research and .

ABSTRACT We investigated the associations between coreceptor use, V3 loop sequence, and CD4 count in a cross-sectional analysis of a large cohort of chronically HIV-infected, treatment-naive patients. HIV coreceptor usage was determined in the last ...

Coreceptor Usage in HIV Infection | IntechOp

Minor or a few sequence alterations or mutations in V3 are sufficient to switch coreceptor use from CCR5 to CXCR4 or from dual-tropic to X4-tropic virus. ...

Different Mutational Pathways to CXCR4 Coreceptor Switch .

Different Mutational Pathways to CXCR4 Coreceptor Switch of CCR5-Using Simian-Human Immunodeficiency Virus Article (PDF Available) in Journal of Virology 82(11):5653-6 · July 2008 with 27 Reads

Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage | AIDS Research and Therapy | Full Te

The actual mutational pathways from a single HIV-1 clone that leads to a phenotypic switch from r5 to x4 may arise with significant cost to replicative fitness []. ...

The R5 to X4 Coreceptor Switch: A Dead-End Path, or a Strategic Maneuver? | SpringerLi

HIV-1 Coreceptor switch Game theory Nash equilibrium Electronic Supplementary Material The online version of this article (doi ... Perelson, A. S., & Davenport, P. M. (2006). Naive and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human, ...

Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade | PN

In subtype B infections, around 50% of patients underwent a coreceptor switch, usually after five years of infection, which correlated with rapid CD4 decline and faster progression to AIDS ...

R5X4 Viruses Are Evolutionary, Functional, and Antigenic .

Thus, dual-tropic viruses represent temporal, evolu- lution of Env variants toward CXCR4 coreceptor usage in both tionary, functional, and antigenic intermediates in the pathway rhesus macaques and humans is at the expense of CCR5 use, to coreceptor switch in rhesus macaques.

Coreceptor use in nonhuman primate models of HIV infection (pdf) | Paperi

of rhesus macaques with CCR5-tropic SHIVs further allows for study of HIV-1 coreceptor switch after intravenous and mucosal inoculation, with longitudinal and systemic analysis to determine the timing, anatomical sites and cause for the change in ...

Co-receptor - Wikiped

The crossover of co-receptor targets for different strains and the ability for the strains to switch from their dominant co-receptor can impede clinical treatment of HIV. Treatments such as WR321 mAb can inhibit some strains of CCR5 HIV-1, preventing cell infection.

CCR5 and CCR5 Screening Assays Comparisons: genotype, 454 Ultra-Deep Sequencing and Trofi

populations at the time of the coreceptor switch comprised mixtures of R5- and dual ... of emerging CXCR4-using variants in the virus populations of eight individuals indicates that HIV uses a multitude of mutational pathways to change from CCR5 to ...