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Role of lubricin and boundary lubrication in the

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Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation .

Superficial zone protein (SZP), also known as lubricin and proteoglycan 4 (PRG4), plays an important role in the boundary lubrication of articular cartilage and is regulated by transforming growth factor (TGF)-β. Here, we evaluate the role of cell surface ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Supramolecular synergy in the boundary lubrication of synovial joints | Nature Communicatio

with a very different role, to provide the boundary lubrication characteristic of healthy synovial joints: ... The role of lubricin in the mechanical behavior of synovial fluid. Proc. Natl Acad. Sci. USA 104, 6194–6199 (2007) . CAS PubMed Article 33. Linn, F . ...

Both Hyaluronan and Collagen Type II Keep Proteoglycan 4 (Lubricin) at the Cartilage Surface in a Condition That Provides Low Friction during .

Wear resistant and ultralow friction in synovial joints is the outcome of a sophisticated synergy between the major macromolecules of the synovial fluid, e.g., hyaluronan ... Abstract: Glycoproteins, such as lubricin, and hyaluronic acid (HA) play a prominent role in ...

Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface | Cornea | JAMA Ophthalmology | JAMA Netwo

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, ... responsible for boundary mode lubrication at the ocular surface supports the hypothesis of Ehlers, 28 who theorized that boundary lubrication must 29 ...

Stribeck Analysis Of Synovial Lubricants: Lubricating Mechanisms And Interaction Of Hyaluronic Acid And Lubric

lubricants: lubricin and hyaluronic acid. Lubricin is an effective boundary lubricant, hyaluronic acid works as a viscosupplement, and interaction between the two lubricants may facilitate changes in lubrication mode. Acknowledgments: The Authors thank the NSF ...

Molecular Aspects of Boundary Lubrication by Human Lubricin: Effect of Disulfide Bonds and Enzymatic Digestion - Langmuir (ACS Publication

Molecular Aspects of Boundary Lubrication by Human Lubricin: Effect of Disulfide Bonds and Enzymatic Digestion† ADVERTISEMENT Log In ...

The role of lubricin in the mechanical behavior of synovial fluid | G D Jay | Request P

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Regulation of lubricin for functional cartilage tissue regeneration: a review - Europe PMC Article - Europe P

The fundamental role of lubricin is lubrication of boundary surface of cartilage []. Hence, transmutation of lubricin metabolism would conspicuously influence joint performance. In fact, patients who suffer from osteoarthritis (OA), degenerative joint disease, or CACP ...

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

The biology of Lubricin: Near frictionless joint motion - ScienceDire

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury .

Objective To study the effect of anterior cruciate ligament (ACL) injury on lubricin concentrations in synovial fluid (SF) and its correlation with time postinjury ... Methods SF samples were obtained from both knees of 30 patients with unilateral ACL insufficiency, 32 ...

NAVER Academic > Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosi

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L Warman, Gregory D Jay Publisher ...

The role of lubricin in the mechanical behavior of synovial flui

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., ... where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure. The role of lubricin in We ...

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubricati

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubrication By Heidi Reesink Abstract ... and galectins-1 and -3 to determine if lubricin and galectins could synergistically enhance articular cartilage boundary lubrication and; 3) evaluate equine ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients ...

Lubrication by biomacromolecules: mechanisms and biomimetic strategies - IOPscien

Waller K A, Zhang L X, Elsaid K A, Fleming B C, Warman M L and Jay G D 2013 Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Proc. Natl Acad. Sci. USA 110 5852–7 ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approach

Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches ...