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Tailored Immunogens Direct Affinity Maturation toward HIV

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Gabriel Ozorows

cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate Antu K. Dey, Albert Cupo, Gabriel Ozorowski, Vaneet K. Sharma Biotechnology and Bioengineering > 115 > 4 > 885 - 899 ...

TSRI and IAVI Researchers Harness Antibody Evolution on the Path to an AIDS Vaccine | Scripps Resear

The first Cell study, “Tailored Immunogens Direct Affinity Maturation Toward HIV Neutralizing Antibodies,” included additional authors from the Ragon Institute. ...

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies: Ce

Development of boosting HIV envelope immunogens designed to guide the genetic and functional maturation of VRC01-class bnAbs provides a roadmap for the ...

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies - ScienceDire

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies Author links open overlay panel Bryan Briney 1 2 3 7 Devin Sok 1 2 3 7 Joseph G. Jardine 1 2 3 7 Daniel W. Kulp ...

Researchers Harness Antibody Evolution on the Path to an AIDS Vaccine | Lab Manag

The first Cell study, “Tailored Immunogens Direct Affinity Maturation Toward HIV Neutralizing Antibodies,” included additional authors from the Ragon Institute. ...

Particle-based Co-delivery of HIV immunogens as Next-generation HIV Vaccines | SBIR.g

NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should use the agency link listed below which will take you directly to ...

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. | PubFac

Natalia de Val, PhD Frederick National Laboratory for Cancer Research Director, Electron Microscopy Laboratory. Team Lead, Cryo-EM at the Center for Molecular Microscopy Electron Microscopy, Structural biology, Vaccine development FREDERICK, MD | United ...

The quest for an antibody-based HIV vaccine - Haynes - 2017 - Immunological Reviews - Wiley Online Libra

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Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design | Retrovirology | Full Te

However, immunization with particulate immunogens expressing high densities of the closely related antigen, duck egg lysozyme ... Menis S, Jacak R, Kalyuzhniy O, de Val N, Sesterhenn F, et al. Tailored immunogens direct affinity maturation toward HIV ...

(PDF) Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodi

PDF | Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engi- neered priming immunogen are relatively common among ...

SciCombinator - Journals - Ce

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies OPEN Cell Published almost 3 years ago Discuss Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are ...

Particle-based Co-delivery of HIV immunogens as Next-generation HIV Vaccines | SBIR.g

HIV immunogens delivered via particle-based modalities may elicit better and improved humoral and cellular immune responses. ... for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity ...

Training human antibodies to protect against HIV | EurekAlert! Science Ne

... Sok, Jardine, Kulp, and Skog et al.: "Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies" http://www.cell.com/cell/fulltext/S0092-8674(16)31054-6 / DOI:10 ...

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies - Europe PMC Article - Europe P

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. (PMID:27610570 PMCID:PMC5018249) Full Text Citations Related Articles Data BioEntities ...

Ward Lab - Publicatio

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Briney B, Sok D, Jardine JG, Kulp DW, Skog P, Menis S ...

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodie

Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. ... View This Abstract Online Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing ...

Strategies to guide the antibody affinity maturation proce

Affinity maturation increases antibody activity through multiple rounds of somatic hypermutation and selection in the germinal center. ... Used immunogens based on HIV sequences isolated at multiple time points during the development of neutralization breadth. ...

Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design | Retrovirology | Full Te

Briney B, Sok D, Jardine JG, Kulp DW, Skog P, Menis S, Jacak R, Kalyuzhniy O, de Val N, Sesterhenn F, et al. Tailored immunogens direct affinity maturation toward HIV ...

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodi

Article Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies Graphical Abstract Highlights d Designed boosting immunogens to follow a VRC01-class germline-targeting prime d Boosted Abs selectively incorporate VRC01-class somatic

Particle-Based Delivery of HIV Env Immunogens | SBIR.g

Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA) ... for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV ...

Researchers harness antibody evolution on the path to an AIDS vacci

"Tailored Immunogens Direct Affinity Maturation Toward HIV Neutralizing Antibodies," Cell, 2016. "Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires," Cell, ...