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Potentiation of the cytotoxicity of thymidylate synthase

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Association of thymidylate synthase variants with 5-fluorour... : Pharmacogenetics and Genomi

Identifying relevant cytotoxicity genes using an ex-vivo lymphoblastoid cell line (LCLs) model has d

Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells — MD Anderson Cancer Cent

the reappearance of catalytically active thymidylate synthase (TS) following 5-fluoro-2'-deoxyuridine exposure, ... N2 - We have investigated the mechanism by which reduced folates, such as folinic acid, enhance the cytotoxicity of fluoropyrimidines ...

Antisense down‐regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5‐FUdR, 5‐FU and Tomudex in HeLa cells .

Thymidylate synthase (TS), the key enzyme in de novo synthesis of thymidine, is an important target for antitumour chemotherapy. It was hypothesized that antisense oligonucleotide down‐regulation of TS mRNA would decrease TS levels and enhance the ...

Cloning, Sequencing, and Expression of the Lactobacillus casei Thymidylate Synthase Gene | D

ABSTRACT The thymidylate synthase (TS) gene from Lactobacillus casei has been isolated, cloned, and sequenced. ... Impact of schedule on leucovorin potentiation of fluorouracil antitumor activity in dietary folic acid deplete mice Biochemical Pharmacology ...

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced -acid glycoprotein bindi

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α 1-acid glycoprotein binding NJ Curtin ...

Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells .

a prodrug of 5-fluorouracil (5-FU); 5-chloro-2,4-dihydroxypyridine (CDHP), an inhibitor of ... Expression of DPD and thymidylate synthase (TS) mRNA was quantified using real-time quantitative polymerase chain reaction analysis. Results (IC 15 ...

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding .

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding Lookup NU author(s): Professor Nicola Curtin, Professor Alan Calvert, Professor Bernard Golding, Professor Roger Griffin, Professor Herbie Newell

18F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplas

Introduction Thymidylate synthase (TS) is an enzyme that plays an important role in the DNA synthesis and catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) (1,2). TS is also a target enzyme of 5 ...

Potentiation of 5-Fluorouracil-Leucovorin Activity by a2a-Interferon in Colon Adenocarcinoma Xenograft

Potentiation of 5-Fluorouracil-Leucovorin Activity by a2a-Interferon in Colon Adenocarcinoma Xenografts1 Janet A Houghton,2 Pamela J. Cheshire, ...

Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity — Johns Hopkins Universi

In Intestine 407 cells the potentiation of 5-FU cytotoxicity by deoxyinosine was even more pronounced at 48 h than at 24 h. ... Culture of cells in the presence of 5-FU and deoxyinosine resulted in an almost complete inhibition of thymidylate synthase activity In ...

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein bindin

Abstract Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the ...

chemotherapy IV Flashcards | Quizl

Explain the mechanisms of resuce of methotrexate and the potentiation of 5-FU by leucovorin ... 5-FU binds to and inhibits thymidylate synthase. Leucovorin stabilizes this interaction. When 6-mercaptopurine is administered to a patient who is on allopurinol ...

Oncotarget | Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABC

Oncotarget (a primarily oncology-focused, peer-reviewed, open access, weekly journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical ...

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein bindi

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α 1-acid glycoprotein binding N J Curtin ...

Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of .

These observations suggest that gefitinib-induced down-regulation of thymidylate synthase is responsible, ... Somatic mutations in the epidermal growth factor receptor ( EGFR ) gene are associated with the therapeutic response to EGFR tyrosine kinase The ...

Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent — Johns Hopkins .

Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent. Advances in Experimental Medicine and Biology, 338, 613-616. Potentiation of 5-fluorouracil induced inhibition of thymidylate ...

Biochemical and Molecular Studies of Human Methenyltetrahydrofolate Syntheta

thymidylate synthase, a protein which catalyzes the transfer of the methylene group from methyleneH4folate to deoxyuridylate to form ... pools and potentiation of 5-FU cytotoxicity in vitro [26-29]. 5-methylH4folate also rapidly appears in plasma following LV 12 ...

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered .

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered ...

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding - CO

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding By N J Curtin, K J Bowman, R N Turner, B Huang, P J Loughlin, A H Calvert, B T Golding, R J Griffin and D R Newell ...

The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition - Semantic Schol

Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Loss of viability following TS inhibition occurs as a consequence of depleted dTTP pools and at least in ...

Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical .

Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: ...